![]() > ALPHA+4G | Premium Anti-vandal GSM intercom - 200 way with keypad.> ALPHA-4G | Premium Anti-vandal GSM intercom - 1 way with keypad.> TEMP-4G | Temperature Monitoring via GSM Auto-dialler.> SPEAK-4G | Remote Loudspeaker Audio Warning System.> LANDLINE-4G | Landline Simulator for PSTN Line Out via GSM Auto-dialler.> PRO+4GMF | Advanced Pro GSM Auto-dialler (with mains fail/restore alert).> PRO+4G | Advanced Professional GSM Auto-dialler.SIGNAL is accessible as a rapid user-friendly web-based application ( ). We describe selection by iterative pathway group and network analysis looping (SIGNAL), an integrated, iterative approach that uses both pathway and network methods to optimize gene prioritization. Using comparative analysis of parallel independent studies as a benchmark, we characterize the specific complementary contributions of each approach and demonstrate an optimal framework to integrate these methods. The specific limitations of these individual approaches and the lack of a systematic way by which to integrate their rankings have contributed to limited overlap in the reported results from comparable genome-wide studies and costly inefficiencies in secondary validation efforts. Widely used methods such as setting of cutoffs, prioritizing pathway enrichments, or incorporating predicted network interactions offer divergent solutions yet are associated with critical analytical trade-offs. Hit selection from high-throughput assays remains a critical bottleneck in realizing the potential of omic-scale studies in biology.
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